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  1. Single-probe analyses in epigenome-wide association studies (EWAS) have identified associations between DNA methylation and many phenotypes, but do not take into account information from neighboring probes. Me...

    Authors: Samantha Lent, Hanfei Xu, Lan Wang, Zhe Wang, Chloé Sarnowski, Marie-France Hivert and Josée Dupuis
    Citation: BMC Genetics 2018 19(Suppl 1):84
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  3. Longitudinal measurement is commonly employed in health research and provides numerous benefits for understanding disease and trait progression over time. More broadly, it allows for proper treatment of correl...

    Authors: Justin C. Strickland, I-Chen Chen, Chanung Wang and David W. Fardo
    Citation: BMC Genetics 2018 19(Suppl 1):82
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  4. GAW20 working group 5 brought together researchers who contributed 7 papers with the aim of evaluating methods to detect genetic by epigenetic interactions. GAW20 distributed real data from the Genetics of Lip...

    Authors: Mariza de Andrade, E. Warwick Daw, Aldi T. Kraja, Virginia Fisher, Lan Wang, Ke Hu, Jing Li, Razvan Romanescu, Jenna Veenstra, Rui Sun, Haoyi Weng and Wenda Zhou
    Citation: BMC Genetics 2018 19(Suppl 1):81
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  5. This paper summarizes the contributions from the Genome-wide Association Study group (GWAS group) of the GAW20. The GWAS group contributions focused on topics such as association tests, phenotype imputation, a...

    Authors: Xuexia Wang, Felix Boekstegers and Regina Brinster
    Citation: BMC Genetics 2018 19(Suppl 1):79
    Content type: Methodology Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  6. An accumulation of evidence has revealed the important role of epigenetic factors in explaining the etiopathogenesis of human diseases. Several empirical studies have successfully incorporated methylation data...

    Authors: Xiaoxuan Xia, Haoyi Weng, Ruoting Men, Rui Sun, Benny Chung Ying Zee, Ka Chun Chong and Maggie Haitian Wang
    Citation: BMC Genetics 2018 19(Suppl 1):78
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  7. Longitudinal data and repeated measurements in epigenome-wide association studies (EWAS) provide a rich resource for understanding epigenetics. We summarize 7 analytical approaches to the GAW20 data sets that ...

    Authors: Haakon E. Nustad, Marcio Almeida, Angelo J. Canty, Marissa LeBlanc, Christian M. Page and Phillip E. Melton
    Citation: BMC Genetics 2018 19(Suppl 1):77
    Content type: Methodology Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  8. Multiple layers of genetic and epigenetic variability are being simultaneously explored in an increasing number of health studies. We summarize here different approaches applied in the Data Mining and Machine ...

    Authors: Burcu Darst, Corinne D. Engelman, Ye Tian and Justo Lorenzo Bermejo
    Citation: BMC Genetics 2018 19(Suppl 1):76
    Content type: Methodology Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  9. Identification of interactions between epigenetic factors and treatments might lead to personalized intervention of diseases. This paper aims to examine the modification effect of fenofibrate therapy on the as...

    Authors: Runmin Wei and Yanyan Wu
    Citation: BMC Genetics 2018 19(Suppl 1):75
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  10. Increasingly available multilayered omics data on large populations has opened exciting analytic opportunities and posed unique challenges to robust estimation of causal effects in the setting of complex disea...

    Authors: Jonathan Auerbach, Richard Howey, Lai Jiang, Anne Justice, Liming Li, Karim Oualkacha, Sergi Sayols-Baixeras and Stella W. Aslibekyan
    Citation: BMC Genetics 2018 19(Suppl 1):74
    Content type: Methodology Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  11. The GAW20 group formed on the theme of methods for association analyses of repeated measures comprised 4sets of investigators. The provided “real” data set included genotypes obtained from a human whole-genome...

    Authors: Saurabh Ghosh and David W. Fardo
    Citation: BMC Genetics 2018 19(Suppl 1):73
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  12. The rise in popularity and accessibility of DNA methylation data to evaluate epigenetic associations with disease has led to numerous methodological questions. As part of GAW20, our working group of 8 research...

    Authors: Angga M. Fuady, Samantha Lent, Chloé Sarnowski and Nathan L. Tintle
    Citation: BMC Genetics 2018 19(Suppl 1):72
    Content type: Methodology Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  13. Rapidly evolving high-throughput technology has made it cost-effective to collect multilevel omic data in clinical and biological studies. Different types of omic data collected from these studies provide both...

    Authors: Xiaoxi Shen and Qing Lu
    Citation: BMC Genetics 2018 19(Suppl 1):71
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  14. In studies with multi-omics data available, there is an opportunity to investigate interdependent mechanisms of biological causality. The GAW20 data set includes both DNA genotype and methylation measures befo...

    Authors: Virginia A. Fisher, Lan Wang, Xuan Deng, Chloé Sarnowski, L. Adrienne Cupples and Ching-Ti Liu
    Citation: BMC Genetics 2018 19(Suppl 1):70
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  15. Transgenerational epigenetic inheritance has been posited as a possible contributor to the observed heritability of metabolic syndrome (MetS). Yet the extent to which estimates of epigenetic inheritance for DN...

    Authors: Lindsay Fernández-Rhodes, Annie Green Howard, Ran Tao, Kristin L. Young, Mariaelisa Graff, Allison E. Aiello, Kari E. North and Anne E. Justice
    Citation: BMC Genetics 2018 19(Suppl 1):69
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  16. We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines ...

    Authors: Jun Young Park, Chong Wu and Wei Pan
    Citation: BMC Genetics 2018 19(Suppl 1):68
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  17. Association studies using a single type of omics data have been successful in identifying disease-associated genetic markers, but the underlying mechanisms are unaddressed. To provide a possible explanation of...

    Authors: Liming Li, Chan Wang, Tianyuan Lu, Shili Lin and Yue-Qing Hu
    Citation: BMC Genetics 2018 19(Suppl 1):67
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  18. An important feature in many genomic studies is quality control and normalization. This is particularly important when analyzing epigenetic data, where the process of obtaining measurements can be bias prone. ...

    Authors: Marissa LeBlanc, Haakon E. Nustad, Manuela Zucknick and Christian M. Page
    Citation: BMC Genetics 2018 19(Suppl 1):66
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  19. Random forest (RF) is a machine-learning method that generally works well with high-dimensional problems and allows for nonlinear relationships between predictors; however, the presence of correlated predictor...

    Authors: Burcu F. Darst, Kristen C. Malecki and Corinne D. Engelman
    Citation: BMC Genetics 2018 19(Suppl 1):65
    Content type: Research Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  20. Fenofibrate (Fb) is a known treatment for elevated triglyceride (TG) levels. The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study was designed to investigate potential contributors to the effect...

    Authors: Svetlana Cherlin, Maggie Haitian Wang, Heike Bickeböller and Rita M. Cantor
    Citation: BMC Genetics 2018 19(Suppl 1):64
    Content type: Methodology Published on:

    This article is part of a Supplement: Volume 19 Supplement 1

  21. Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associa...

    Authors: Brandon D. Velie, Kim Jäderkvist Fegraeus, Marina Solé, Maria K. Rosengren, Knut H. Røed, Carl-Fredrik Ihler, Eric Strand and Gabriella Lindgren
    Citation: BMC Genetics 2018 19:80
    Content type: Research article Published on:

  22. Increasing grain yield is a primary objective of maize breeding. Dissecting the genetic architecture of grain yield furthers genetic improvements to increase yield. Presented here is an association panel compo...

    Authors: Ting Li, Jianzhou Qu, Yahui Wang, Liguo Chang, Kunhui He, Dongwei Guo, Xinghua Zhang, Shutu Xu and Jiquan Xue
    Citation: BMC Genetics 2018 19:63
    Content type: Research article Published on:

  23. One of the most popular ornamental plants worldwide, roses (Rosa sp.), are very susceptible to Botrytis gray mold disease. The necrotrophic infection of rose petals by B. cinerea causes the collapse and death of ...

    Authors: Xintong Liu, Xiaoqian Cao, Shaochuan Shi, Na Zhao, Dandan Li, Peihong Fang, Xi Chen, Weicong Qi and Zhao Zhang
    Citation: BMC Genetics 2018 19:62
    Content type: Research article Published on:

  24. NOD-like receptors (NLRs) are a family of cytoplasmic pattern recognition receptors (PRRs), of which NOD1 and NOD2, are the main representative members. Many investigations have focused on the role of NOD1 and NO...

    Authors: Tiantian Gu, Lu Lu, Jingwen Wang, Lili Tian, Wenzhi Wei, Xinsheng Wu, Qi Xu and Guohong Chen
    Citation: BMC Genetics 2018 19:61
    Content type: Research article Published on:

  25. Previous studies on linkage disequilibrium have investigated second order linkage disequilibrium in animal and plant populations. The objective of this paper was to investigate the genome-wide levels of third ...

    Authors: Luis Gomez-Raya, Luis Silio, Wendy M. Rauw, Luis Alberto Gracia-Cortés and Carmen Rodríguez
    Citation: BMC Genetics 2018 19:60
    Content type: Research article Published on:

  26. The changing climate is altering timing of key fruit ripening processes and increasing the occurrence of fruit defects. To improve our understanding of the genetic control of raspberry fruit development an enh...

    Authors: Christine A. Hackett, Linda Milne, Kay Smith, Pete Hedley, Jenny Morris, Craig G. Simpson, Katharine Preedy and Julie Graham
    Citation: BMC Genetics 2018 19:59
    Content type: Research article Published on:

  27. Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon expos...

    Authors: Md Tarikul Islam, Suprovath Kumar Sarker, Shezote Talukder, Golam Sarower Bhuyan, Asifuzzaman Rahat, Nafisa Nawal Islam, Hasan Mahmud, Mohammad Amir Hossain, A. K. M. Muraduzzaman, Jakia Rahman, Syeda Kashfi Qadri, Mohammod Shahidullah, Mohammad Abdul Mannan, Sarabon Tahura, Manzoor Hussain, Narayan Saha…
    Citation: BMC Genetics 2018 19:58
    Content type: Methodology article Published on:

  28. Rolling of leaves (RL) is a phenomenon commonly found in grasses. Morphology of the leaf is an important agronomic trait in field crops especially in rice; therefore, majority of the rice breeders are interest...

    Authors: Beata Myśków, Magdalena Góralska, Natalia Lenarczyk, Ilona Czyczyło-Mysza and Stefan Stojałowski
    Citation: BMC Genetics 2018 19:57
    Content type: Research article Published on:

  29. SNPs are informative to estimate genomic breed composition (GBC) of individual animals, but selected SNPs for this purpose were not made available in the commercial bovine SNP chips prior to the present study....

    Authors: Jun He, Yage Guo, Jiaqi Xu, Hao Li, Anna Fuller, Richard G. Tait Jr, Xiao-Lin Wu and Stewart Bauck
    Citation: BMC Genetics 2018 19:56
    Content type: Research article Published on:

  30. Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem ...

    Authors: I-Hsuan Lin, Junn-Liang Chang, Kate Hua, Wan-Chen Huang, Ming-Ta Hsu and Yi-Fan Chen
    Citation: BMC Genetics 2018 19:55
    Content type: Research article Published on:

  31. Numerous studies have demonstrated significant differences in the expression level across continental human populations. Most of published results were performed on B-cell lines materials examined under specif...

    Authors: P. Daca-Roszak, M. Swierniak, R. Jaksik, T. Tyszkiewicz, M. Oczko-Wojciechowska, J. Zebracka-Gala, B. Jarzab, M. Witt and E. Zietkiewicz
    Citation: BMC Genetics 2018 19:54
    Content type: Research article Published on:

  34. The ability of maize populations/landraces to tolerate drastically extreme environments over the past four centuries in Algeria leads to characterize these genetic resources for germplasm management as well as...

    Authors: Miyassa Meriem Aci, Antonio Lupini, Antonio Mauceri, Abdelkader Morsli, Lakhdar Khelifi and Francesco Sunseri
    Citation: BMC Genetics 2018 19:51
    Content type: Research article Published on:

  35. The Hessian fly response genes, Hfr-1 and Hfr-2, have been reported to be significantly induced in a Hessian fly attack. Nothing is known about the allelic variants of these two genes in susceptible (S) and resis...

    Authors: Mui-Keng Tan, Mustapha El-Bouhssini, Ossie Wildman, Wuletaw Tadesse, Grant Chambers, Shuming Luo and Livinus Emebiri
    Citation: BMC Genetics 2018 19:50
    Content type: Research article Published on:

  36. Many common and relevant diseases affecting equine welfare have yet to be tested regarding structural variants such as copy number variations (CNVs). CNVs make up a substantial proportion of total genetic vari...

    Authors: Anouk Schurink, Vinicius H. da Silva, Brandon D. Velie, Bert W. Dibbits, Richard P. M. A. Crooijmans, Liesbeth Franҫois, Steven Janssens, Anneleen Stinckens, Sarah Blott, Nadine Buys, Gabriella Lindgren and Bart J. Ducro
    Citation: BMC Genetics 2018 19:49
    Content type: Research article Published on:

  37. WRKY transcription factors (TFs) participate in various physiological processes of plants. Although WRKY genes have been well studied in model plants, knowledge of the functional roles of these genes is still ...

    Authors: Lijiao Gu, Hengling Wei, Hantao Wang, Junji Su and Shuxun Yu
    Citation: BMC Genetics 2018 19:48
    Content type: Research article Published on:

  39. This study aimed to explore the molecular mechanism of estrogen-mediated neuroprotection in the relief of cerebral ischemic injury. The gene expression profiles were downloaded from Gene Expression Omnibus dat...

    Authors: Jiaxuan He, Ya Gao, Gang Wu, Xiaoming Lei, Yong Zhang, Weikang Pan and Hui Yu
    Citation: BMC Genetics 2018 19:46
    Content type: Research article Published on:

  40. Glutathione S-transferases (GSTs) have been reported to regulate the plant tolerance to environmental stresses. Many plant GSTs exhibited the roles on promoting tolerance to drought stress, oxidative stress an...

    Authors: Wenbin Liao, Shuxia Li, Cheng Lu and Ming Peng
    Citation: BMC Genetics 2018 19:45
    Content type: Research article Published on:

  41. Following publication of the original article [1], the authors reported the need for a more detailed acknowledgement of the source of the samples that were analyzed and their coordinates, which are discussed i...

    Authors: Samer Omari, Yuri Kamenir, Jennifer I. C. Benichou, Sarah Pariente, Hanan Sela and Rafael Perl-Treves
    Citation: BMC Genetics 2018 19:44
    Content type: Correction Published on:

    The original article was published in BMC Genetics 2018 19:34

  42. Photobacteriosis is an infectious disease developed by a Gram-negative bacterium Photobacterium damselae subsp. piscicida (Phdp), which may cause high mortalities (90–100%) in sea bream. Selection and breeding fo...

    Authors: Muhammad L Aslam, Roberta Carraro, Anastasia Bestin, Sophie Cariou, Anna K. Sonesson, Jean-Sébastien Bruant, Pierrick Haffray, Luca Bargelloni and Theo H. E. Meuwissen
    Citation: BMC Genetics 2018 19:43
    Content type: Research article Published on:

  43. Atlantic cod (Gadus morhua L.) has formed the basis of many economically significant fisheries in the North Atlantic, and is one of the best studied marine fishes, but a legacy of overexploitation has depleted po...

    Authors: Geir Dahle, María Quintela, Torild Johansen, Jon-Ivar Westgaard, François Besnier, Asgeir Aglen, Knut E. Jørstad and Kevin A. Glover
    Citation: BMC Genetics 2018 19:42
    Content type: Research article Published on:

  45. Electrical status epilepticus during slow-wave sleep (ESESS) which is also known as continuous spike-wave of slow sleep (CSWSS) is type of electroencephalographic (EEG) pattern which is seen in ESESS/CSWSS/epi...

    Authors: Miriam Kessi, Jing Peng, Lifen Yang, Juan Xiong, Haolin Duan, Nan Pang and Fei Yin
    Citation: BMC Genetics 2018 19:40
    Content type: Research article Published on:

  46. Anterior cruciate ligament rupture (ACLR) is a debilitating and potentially life-changing condition in humans, as there is a high prevalence of early-onset osteoarthritis after injury. Identification of high-r...

    Authors: Lauren A. Baker, Guilherme J. M. Rosa, Zhengling Hao, Alexander Piazza, Christopher Hoffman, Emily E. Binversie, Susannah J. Sample and Peter Muir
    Citation: BMC Genetics 2018 19:39
    Content type: Research article Published on:

  48. Identification of genetic mechanisms and idiosyncrasies at the breed-level can provide valuable information for potential use in evolutionary studies, medical applications, and breeding of selective traits. He...

    Authors: Kelsey Caetano-Anolles, Kwondo Kim, Woori Kwak, Samsun Sung, Heebal Kim, Bong-Hwan Choi and Dajeong Lim
    Citation: BMC Genetics 2018 19:37
    Content type: Research article Published on:

  49. The changing climate and the desire to use renewable oil sources necessitate the development of new oilseed crops. Field cress (Lepidium campestre) is a species in the Brassicaceae family that has been targeted f...

    Authors: Cecilia Gustafsson, Jakob Willforss, Fernando Lopes-Pinto, Rodomiro Ortiz and Mulatu Geleta
    Citation: BMC Genetics 2018 19:36
    Content type: Research article Published on:

  50. Genomic selection (GS) can accelerate genetic gains in breeding programmes by reducing the time it takes to complete a cycle of selection. Puccinia coronata f. sp lolli (crown rust) is one of the most widespread ...

    Authors: Sai Krishna Arojju, Patrick Conaghan, Susanne Barth, Dan Milbourne, Michael D. Casler, Trevor R. Hodkinson, Thibauld Michel and Stephen L. Byrne
    Citation: BMC Genetics 2018 19:35
    Content type: Research article Published on:
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