Skip to main content

Articles

Page 40 of 49

  1. DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for extreme early onset obesity dete...

    Authors: Susann Friedel, Kathrin Reichwald, André Scherag, Harald Brumm, Anne-Kathrin Wermter, Hans-Rudolf Fries, Kerstin Koberwitz, Martin Wabitsch, Thomas Meitinger, Matthias Platzer, Heike Biebermann, Anke Hinney and Johannes Hebebrand
    Citation: BMC Genetics 2007 8:17
    Content type: Research article Published on:

  2. The long bone abnormality (lbab) mouse is a new autosomal recessive mutant characterized by overall smaller body size with proportionate dwarfing of all organs and shorter long bones. Previous linkage analysis ha...

    Authors: Yan Jiao, Jian Yan, Feng Jiao, HongBin Yang, Leah Rae Donahue, Xinmin Li, Bruce A Roe, John Stuart and Weikuan Gu
    Citation: BMC Genetics 2007 8:16
    Content type: Research article Published on:

  3. Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In ...

    Authors: Bianca Haase, Marcus G Doherr, Torsten Seuberlich, Cord Drögemüller, Gaudenz Dolf, Petra Nicken, Katrin Schiebel, Ute Ziegler, Martin H Groschup, Andreas Zurbriggen and Tosso Leeb
    Citation: BMC Genetics 2007 8:15
    Content type: Research article Published on:

  4. The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association.

    Authors: Viviana Romero, Charles E Larsen, Jonathan S Duke-Cohan, Edward A Fox, Tatiana Romero, Olga P Clavijo, Dolores A Fici, Zaheed Husain, Ingrid Almeciga, Dennis R Alford, Zuheir L Awdeh, Joaquin Zuñiga, Lama El-Dahdah, Chester A Alper and Edmond J Yunis
    Citation: BMC Genetics 2007 8:14
    Content type: Research article Published on:

  5. Cigarette smoking and chemical occupational exposure are the main known risk factors for bladder transitional cell carcinoma (TCC). Oxidative DNA damage induced by carcinogens present in these exposures requir...

    Authors: Sei Chung Sak, Jennifer H Barrett, Alan B Paul, D Timothy Bishop and Anne E Kiltie
    Citation: BMC Genetics 2007 8:13
    Content type: Research article Published on:

  6. India has experienced several waves of migration since the Middle Paleolithic. It is believed that the initial demic movement into India was from Africa along the southern coastal route, approximately 60,000–8...

    Authors: Faisal Khan, Atul Kumar Pandey, Manorma Tripathi, Sudha Talwar, Prakash S Bisen, Minal Borkar and Suraksha Agrawal
    Citation: BMC Genetics 2007 8:12
    Content type: Research article Published on:

  7. Sry is a gene known to be essential for testis determination but is also transcribed in adult male tissues. The laboratory rat, Rattus norvegicus, has multiple Y chromosome copies of Sry while most mammals have o...

    Authors: Monte E Turner, Carey Martin, Almir S Martins, Jeffrey Dunmire, Joel Farkas, Daniel L Ely and Amy Milsted
    Citation: BMC Genetics 2007 8:11
    Content type: Research article Published on:

  8. Classical genetic studies indicate that nicotine dependence is a substantially heritable complex disorder. Genetic vulnerabilities to nicotine dependence largely overlap with genetic vulnerabilities to depende...

    Authors: George R Uhl, Qing-Rong Liu, Tomas Drgon, Catherine Johnson, Donna Walther and Jed E Rose
    Citation: BMC Genetics 2007 8:10
    Content type: Research article Published on:

  10. Mitochondrial DNA (mtDNA) mutations are of increasing interest due to their involvement in aging, disease, fertility, and their role in the evolution of the mitochondrial genome. The presence of reactive oxyge...

    Authors: Wei-Siang Liau, Aidyl S Gonzalez-Serricchio, Cleonique Deshommes, Kara Chin and Craig W LaMunyon
    Citation: BMC Genetics 2007 8:8
    Content type: Research article Published on:

  11. Allele frequencies reported from public databases or articles are mostly based on small sample sizes. Differences in genotype frequencies by age, race and sex have implications for studies designed to examine ...

    Authors: Han-Yao Huang, Lucy Thuita, Paul Strickland, Sandra C Hoffman, George W Comstock and Kathy J Helzlsouer
    Citation: BMC Genetics 2007 8:7
    Content type: Research article Published on:

  12. Giant axonal neuropathy (GAN) is a hereditary neurological disorder that affects both central and peripheral nerves. The main pathological hallmark of the disease is abnormal accumulations of intermediate fila...

    Authors: Conrad L Leung, Yinghua Pang, Chang Shu, Dmitry Goryunov and Ronald KH Liem
    Citation: BMC Genetics 2007 8:6
    Content type: Research article Published on:

  13. Isolated syndactyly in cattle, also known as mulefoot, is inherited as an autosomal recessive trait with variable penetrance in different cattle breeds. Recently, two independent mutations in the bovine LRP4 gene...

    Authors: Cord Drögemüller, Tosso Leeb, Barbara Harlizius, Imke Tammen, Ottmar Distl, Martin Höltershinken, Arcangelo Gentile, Amandine Duchesne and André Eggen
    Citation: BMC Genetics 2007 8:5
    Content type: Research article Published on:

  14. Diseases of cartilage, such as arthritis and degenerative disc disease, affect the majority of the general population, particularly with ageing. Discovery and understanding of the genes and pathways involved i...

    Authors: Ming-Yiu Yeung, David K Smith, Matthew SY Chan, Cheuk M Li, Brian C Wong, Kenneth MC Cheung, Keith DK Luk, Kathryn SE Cheah, Pak Sham, Danny Chan and You-Qiang Song
    Citation: BMC Genetics 2007 8:4
    Content type: Database Published on:

  15. Late onset Alzheimer's disease (LOAD) is a common sporadic form of the illness, affecting individuals above the age of 65 yrs. A prominent hypothesis for the aetiopathology of Alzheimer's disease is that in th...

    Authors: Odity Mukherjee, John SK Kauwe, Kevin Mayo, John C Morris and Alison M Goate
    Citation: BMC Genetics 2007 8:3
    Content type: Research article Published on:

  18. There are at least 25 human selenoproteins, each characterized by the incorporation of selenium into the primary sequence as the amino acid selenocysteine. Since many selenoproteins have antioxidant properties...

    Authors: Charles B Foster, Kshama Aswath, Stephen J Chanock, Heather F McKay and Ulrike Peters
    Citation: BMC Genetics 2006 7:56
    Content type: Research article Published on:

  19. The link between host MHC (major histocompatibility complex) genotype and malaria is largely based on correlative data with little or no experimental control of potential confounding factors. We used an experi...

    Authors: Claus Wedekind, Mirjam Walker and Tom J Little
    Citation: BMC Genetics 2006 7:55
    Content type: Research article Published on:

  20. Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has be...

    Authors: Yuguo Chen, Chia-Ho Lin and Chiara Sabatti
    Citation: BMC Genetics 2006 7:54
    Content type: Software Published on:

  21. Congenital nephrogenic diabetes insipidus (NDI) is a rare X-linked inherited disorder characterized by the excretion of large volumes of diluted urine and caused by mutations in arginine vasopressin receptor 2...

    Authors: Yan Dong, Haihui Sheng, Xueru Chen, Jun Yin and Qing Su
    Citation: BMC Genetics 2006 7:53
    Content type: Research article Published on:

  23. Bovine spongiform encephalopathy (BSE) is a fatal neurological disorder characterized by abnormal deposits of a protease-resistant isoform of the prion protein. Characterizing linkage disequilibrium (LD) and h...

    Authors: Michael L Clawson, Michael P Heaton, John W Keele, Timothy PL Smith, Gregory P Harhay and William W Laegreid
    Citation: BMC Genetics 2006 7:51
    Content type: Research article Published on:

  24. Genetic association studies aim at finding correlations between a disease state and genetic variations such as SNPs or combinations of SNPs, termed haplotypes. Some haplotypes have a particular biological mean...

    Authors: Cédric Coulonges, Olivier Delaneau, Manon Girard, Hervé Do, Ronald Adkins, Jean-Louis Spadoni and Jean-François Zagury
    Citation: BMC Genetics 2006 7:50
    Content type: Research article Published on:

  27. Anosmin-1, the protein implicated in the X-linked Kallmann's syndrome, plays a role in axon outgrowth and branching but also in epithelial morphogenesis. The molecular mechanism of its action is, however, wide...

    Authors: Davide Andrenacci, Maria R Grimaldi, Vittorio Panetta, Elena Riano, Elena I Rugarli and Franco Graziani
    Citation: BMC Genetics 2006 7:47
    Content type: Research article Published on:

  28. The Silver coat color, also called Silver dapple, in the horse is characterized by dilution of the black pigment in the hair. This phenotype shows an autosomal dominant inheritance. The effect of the mutation ...

    Authors: Emma Brunberg, Leif Andersson, Gus Cothran, Kaj Sandberg, Sofia Mikko and Gabriella Lindgren
    Citation: BMC Genetics 2006 7:46
    Content type: Research article Published on:

  29. Population genetic studies of dogs have so far mainly been based on analysis of mitochondrial DNA, describing only the history of female dogs. To get a picture of the male history, as well as a second independ...

    Authors: Christian Natanaelsson, Mattias CR Oskarsson, Helen Angleby, Joakim Lundeberg, Ewen Kirkness and Peter Savolainen
    Citation: BMC Genetics 2006 7:45
    Content type: Research article Published on:

  30. The Dlk1 and Gtl2 genes define a region of mouse chromosome 12 that is subject to genomic imprinting, the parental allele-specific expression of a gene. Although imprinted genes play important roles in growth and...

    Authors: Ekaterina Y Steshina, Michael S Carr, Elena A Glick, Aleksey Yevtodiyenko, Oliver K Appelbe and Jennifer V Schmidt
    Citation: BMC Genetics 2006 7:44
    Content type: Research article Published on:

  32. India is a country with enormous social and cultural diversity due to its positioning on the crossroads of many historic and pre-historic human migrations. The hierarchical caste system in the Hindu society do...

    Authors: Ismail Thanseem, Kumarasamy Thangaraj, Gyaneshwer Chaubey, Vijay Kumar Singh, Lakkakula VKS Bhaskar, B Mohan Reddy, Alla G Reddy and Lalji Singh
    Citation: BMC Genetics 2006 7:42
    Content type: Research article Published on:

  33. X chromosome inactivation (XCI) is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes ...

    Authors: Stanley M Gartler, Kartik R Varadarajan, Ping Luo, Thomas H Norwood, Theresa K Canfield and R Scott Hansen
    Citation: BMC Genetics 2006 7:41
    Content type: Research article Published on:

  36. Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs i...

    Authors: Rasika A Mathias, Peisong Gao, Janet L Goldstein, Alexander F Wilson, Elizabeth W Pugh, Paulette Furbert-Harris, Georgia M Dunston, Floyd J Malveaux, Alkis Togias, Kathleen C Barnes, Terri H Beaty and Shau-Ku Huang
    Citation: BMC Genetics 2006 7:38
    Content type: Research article Published on:

  38. Targeting the green fluorescent protein (GFP) via the E. coli lac repressor (LacI) to a specific DNA sequence, the lac operator (lacO), allows visualization of chromosomes in yeast and mammalian cells. In princip...

    Authors: Aidyl S Gonzalez-Serricchio and Paul W Sternberg
    Citation: BMC Genetics 2006 7:36
    Content type: Methodology article Published on:

  39. Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and ex...

    Authors: Hyun Sub Cheong, Du-Hak Yoon, Lyoung Hyo Kim, Byung Lae Park, Yoo Hyun Choi, Eui Ryong Chung, Yong Min Cho, Eng Woo Park, Il-Cheong Cheong, Sung-Jong Oh, Sung-Gon Yi, Taesung Park and Hyoung Doo Shin
    Citation: BMC Genetics 2006 7:35
    Content type: Research article Published on:

  40. Brahma (BRM) is a key component of the multisubunit SWI/SNF complex, a complex which uses the energy of ATP hydrolysis to remodel chromatin. BRM contains an N-terminal polyglutamine domain, encoded by a polymo...

    Authors: Sarojini Sengupta, Lan Xiong, Ferid Fathalli, Chawki Benkelfat, Karim Tabbane, Zoltan Danics, Alain Labelle, Samarthji Lal, Marie-Odile Krebs, Guy Rouleau and Ridha Joober
    Citation: BMC Genetics 2006 7:34
    Content type: Research article Published on:

  41. The asymmetric segregation of determinants during cell division is a fundamental mechanism for generating cell fate diversity during development. In Drosophila, neural precursors (neuroblasts) divide in a stem ce...

    Authors: Cathy Slack, W Gregory Somers, Rita Sousa-Nunes, William Chia and Paul M Overton
    Citation: BMC Genetics 2006 7:33
    Content type: Research article Published on:

  42. The acquisition of high-quality DNA for use in phylogenetic and molecular population genetic studies is a primary concern for evolutionary and genetic researchers. Many non-destructive DNA sampling methods hav...

    Authors: James J Campanella and John V Smalley
    Citation: BMC Genetics 2006 7:32
    Content type: Methodology article Published on:

  44. High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and ...

    Authors: Daniel Levy, Steven R DePalma, Emelia J Benjamin, Christopher J O'Donnell, Helen Parise, Joel N Hirschhorn, Ramachandran S Vasan, Seigo Izumo and Martin G Larson
    Citation: BMC Genetics 2006 7:30
    Content type: Methodology article Published on:

  45. Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholester...

    Authors: Kaori Nakamoto, Shuang Wang, Robert D Jenison, Grace L Guo, Curtis D Klaassen, Yu-Jui Yvonne Wan and Xiao-bo Zhong
    Citation: BMC Genetics 2006 7:29
    Content type: Research article Published on:

  46. Indian populations endowed with unparalleled genetic complexity have received a great deal of attention from scientists world over. However, the fundamental question over their ancestry, whether they are all g...

    Authors: VK Kashyap, Saurav Guha, T Sitalaximi, G Hima Bindu, Seyed E Hasnain and R Trivedi
    Citation: BMC Genetics 2006 7:28
    Content type: Research article Published on:

  48. Egg production is of critical importance in birds not only for their reproduction but also for human consumption as the egg is a highly nutritive and balanced food. Consequently, laying in poultry has been imp...

    Authors: Francis Minvielle, Boniface B Kayang, Miho Inoue-Murayama, Mitsuru Miwa, Alain Vignal, David Gourichon, André Neau, Jean-Louis Monvoisin and Shin' ichi Ito
    Citation: BMC Genetics 2006 7:26
    Content type: Research article Published on:

  49. Inguinal and scrotal hernias are of great concern to pig producers, and lead to poor animal welfare and severe economic loss. Selection against these conditions is highly preferable, but at this time no gene, ...

    Authors: Eli Grindflek, Maren Moe, Helge Taubert, Henner Simianer, Sigbjørn Lien and Thomas Moen
    Citation: BMC Genetics 2006 7:25
    Content type: Research article Published on:

  50. In the field of statistical genetics, phenotype and genotype misclassification errors can substantially reduce power to detect association with genetic case/control studies. Misclassification also can bias pop...

    Authors: Sandra Barral, Chad Haynes, Millicent Stone and Derek Gordon
    Citation: BMC Genetics 2006 7:24
    Content type: Software Published on:
Submit manuscript

Annual Journal Metrics

  • For BMC Genetics (former title)

    2022 Citation Impact
    2.9 - 2-year Impact Factor
    3.2 - 5-year Impact Factor
    0.904 - SNIP (Source Normalized Impact per Paper)
    0.642 - SJR (SCImago Journal Rank)

    2023 Speed
    33 days submission to first editorial decision for all manuscripts (Median)
    168 days submission to accept (Median)

    2023 Usage  
    899,475 downloads
    478 Altmetric mentions

Follow

Sign up for article alerts and news from this journal

BMC Genomic Data

ISSN: 2730-6844

Contact us