Identification of genetic variants associated with anterior cruciate ligament rupture and AKC standard coat color in the Labrador Retriever

Table 2 SNPs associated with the multivariate phenotype of ACL rupture and coat color in the Labrador Retriever using linear mixed model GWAS with GEMMA [35]

Chr	Position	Number of SNPs	P-value	Gene	Location	Distance (bp)
5	63,697,949	1	3.95E-45	TCF25	63,697,627–63,729,780	0
5	64,046,368–64,095,007	9	5.48E-26–1.64E-25	ANKRD11	64,047,188–64,229,582	0
7	49,455,960	1	5.97E-07	lncRNA	49,407,711–49,493,131	0
23	32,670,460	1	3.19E-07	PCCB	32,689,873–32,782,007	19,413
23	32,670,460	1	3.19E-07	MSL2	32,631,936–32,662,611	7849
24	34,877,398	1	3.14E-07	non-coding	n/a	n/a
24	34,983,528	1	3.62E-07	non-coding	n/a	n/a
24	38,868,995	1	1.83E-07	non-coding	n/a	n/a
30	29,741,631	1	2.25E-08	IGDCC3	29,702,195–29,743,079	0

Note: There was a large area spanning approximately 8 Mb on chromosome 5 that contains 331 SNPs, including the one with the most significant association. Only the top 10 SNPs on chromosome 5 are presented in the table. Genes within ±25 kb of each SNP are reported

ISSN: 2730-6844