From: Gene-based burden scores identify rare variant associations for 28 blood biomarkers
Biomarker | Gene predictors | Covariates Model R2 | Incremental R2 | ||
---|---|---|---|---|---|
 |  |  | Genes | PRS | Combined |
Alanine aminotransferase | 4 | 0.137 | 0.003 | 0.011 | 0.014 |
Albumin | 5 | 0.059 | 0.005 | 0.027 | 0.032 |
Alkaline Phosphatase | 8 | 0.071 | 0.026 | 0.088 | 0.103 |
Apolipoprotein A | 11 | 0.208 | 0.009 | 0.075 | 0.083 |
Apolipoprotein Ba | 5 | 0.088 | 0.007 | 0.157 | 0.162 |
Aspartate Aminotransferase | 10 | 0.040 | 0.000 | 0.009 | 0.009 |
Calcium | 2 | 0.028 | 0.002 | 0.017 | 0.018 |
Cholesterola | 6 | 0.089 | 0.006 | 0.096 | 0.099 |
C-reactive protein | 5 | 0.066 | 0.004 | 0.009 | 0.011 |
Creatinine | 41 | 0.248 | -0.006 | 0.011 | 0.005 |
Cystatin C | 11 | 0.177 | -0.001 | 0.043 | 0.043 |
Direct bilirubin | 14 | 0.045 | 0.011 | 0.272 | 0.272 |
Gamma glutamyltransferase | 11 | 0.053 | 0.001 | 0.015 | 0.015 |
Glucose | 8 | 0.030 | 0.001 | 0.003 | 0.003 |
Glycated haemoglobin (HbA1c) | 16 | 0.098 | 0.001 | 0.020 | 0.022 |
HDL cholesterol | 14 | 0.274 | 0.011 | 0.113 | 0.120 |
IGF1 | 5 | 0.091 | 0.003 | 0.067 | 0.070 |
LDL directa | 5 | 0.077 | 0.006 | 0.109 | 0.113 |
Lipoprotein A | 3 | 0.000 | 0.003 | 0.567 | 0.591 |
Phosphate | 3 | 0.067 | 0.003 | 0.020 | 0.023 |
SHBG | 5 | 0.309 | 0.017 | 0.053 | 0.065 |
Testosterone | 1 | 0.828 | 0.001 | 0.006 | 0.008 |
Total bilirubin | 11 | 0.064 | 0.012 | 0.399 | 0.400 |
Total protein | 4 | 0.003 | 0.005 | 0.039 | 0.042 |
Triglycerides | 7 | 0.139 | 0.003 | 0.058 | 0.061 |
Urate | 4 | 0.387 | 0.013 | 0.065 | 0.077 |
Urea | 2 | 0.070 | 0.000 | 0.009 | 0.010 |
Vitamin D | 2 | 0.040 | 0.001 | 0.015 | 0.015 |