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Table 2 The R2 of prediction models for blood biomarkers, with calculated incremental R2 values between covariates only model and the rest of the models

From: Gene-based burden scores identify rare variant associations for 28 blood biomarkers

Biomarker

Gene predictors

Covariates Model R2

Incremental R2

   

Genes

PRS

Combined

Alanine aminotransferase

4

0.137

0.003

0.011

0.014

Albumin

5

0.059

0.005

0.027

0.032

Alkaline Phosphatase

8

0.071

0.026

0.088

0.103

Apolipoprotein A

11

0.208

0.009

0.075

0.083

Apolipoprotein Ba

5

0.088

0.007

0.157

0.162

Aspartate Aminotransferase

10

0.040

0.000

0.009

0.009

Calcium

2

0.028

0.002

0.017

0.018

Cholesterola

6

0.089

0.006

0.096

0.099

C-reactive protein

5

0.066

0.004

0.009

0.011

Creatinine

41

0.248

-0.006

0.011

0.005

Cystatin C

11

0.177

-0.001

0.043

0.043

Direct bilirubin

14

0.045

0.011

0.272

0.272

Gamma glutamyltransferase

11

0.053

0.001

0.015

0.015

Glucose

8

0.030

0.001

0.003

0.003

Glycated haemoglobin (HbA1c)

16

0.098

0.001

0.020

0.022

HDL cholesterol

14

0.274

0.011

0.113

0.120

IGF1

5

0.091

0.003

0.067

0.070

LDL directa

5

0.077

0.006

0.109

0.113

Lipoprotein A

3

0.000

0.003

0.567

0.591

Phosphate

3

0.067

0.003

0.020

0.023

SHBG

5

0.309

0.017

0.053

0.065

Testosterone

1

0.828

0.001

0.006

0.008

Total bilirubin

11

0.064

0.012

0.399

0.400

Total protein

4

0.003

0.005

0.039

0.042

Triglycerides

7

0.139

0.003

0.058

0.061

Urate

4

0.387

0.013

0.065

0.077

Urea

2

0.070

0.000

0.009

0.010

Vitamin D

2

0.040

0.001

0.015

0.015

  1. a Values adjusted for statins