Fig. 4

Main altered processes in CD34 + cells from BM and PB neutrophils from ET patients with JAK2 mutations. Hallmarks found in (a) BM CD34 + cells and (b) PB neutrophils from ET patients with JAK2 mutations using the GSEA normalized enrichment scores. A darker red color is indicative of a lower GSEA-adjusted p-value. The uncolored hallmarks are common to both types of samples while the yellow and red colored hallmarks are exclusive to BM CD34 + cells and PB neutrophils, respectively. (c) Venn diagrams that summarize the main altered processes in BM CD34 + cells and PB neutrophils and common gene expression signature for both cell types