Table 3 Key components of the Notch signaling pathway retrieved from the database. Each line corresponds to the gene name, gene group, and its role in the pathway. In addition, we list the number of sequences retrieved from EchinoDB, EchinoidDB and OphiuroidDB using “keyword” and “BLAST” search. Column search type represents K for keyword search and B for BLAST search. Number 0 represents no sequence found in the corresponding database for that gene

Motif

A disintegrin and metalloproteinase with thrombospondin motifs

ADAM 10/17

K

344

2

83

[72]

Receptor

Receptor proteolysis

Presenilin 1

K

77

2

3

[16, 72]

Transcription factor

HES-4-like

HES

K

46

3

3

[16]

Auxiliary protein

Mastermind-like protein. Co-activator of RBP-J

Mastermind

B

122

8

6

[72, 87]

Enzyme

E3 ubiquitin-protein ligase

Mindbomb

K

282

188

367

[16]

Protein coding

Notch Activation Complex Kinase. Co-activator of RBP-J

NACK

K

68

3

6

[16]

Transcription factor

CREB-binding protein. Co-activator of RBP-J

p300

K

103

2

2

[16]

Receptor

Neurogenic locus notch

Notch

K

14

35

50

[72, 88]

Receptor

Receptor proteolysis

Nicastrin

K

68

1

1

[72, 89]

Regulator

Negative regulator of the Notch pathway

Numb

K

68

0

1

[89]

Regulator

Context-dependent positive or negative regulator

Notchless

K

200

1

10

[90]

Regulator

Neuronal precursor cell-Expressed. Targets Notch and Deltex for degradation

Nedd4

K

94

2

2

[91]

Regulator

E3 ubiquitin-protein ligase/ DTX1. Context-dependent positive or negative regulator. Antagonizes Nedd4

Deltex

K

139

0

0

[74, 91]

Transcription factor

Mesoderm posterior bHLH transcription factor 2. Activates Fringe, induces degradation of Mastermind

Mesp2

B

6

2

1

[88]

Ligand

Ubiquitination of Jagged

Neuralized

K

159

6

26

[16]

Receptor

Ligand of the notch receptor

Delta/Serrate (Jagged)

K

68

2

2

[16]

Transcription factor

CBF1/ Recombination signal binding protein for immunoglobulin kappa J region. Transcription factor activated by Notch

RBP-J

K

1

1

0

[16, 72]

Regulator

Numb-associated kinase. Positive regulator of the Notch pathway

NAK

B

500

39

78

[16, 72]

Activator

Acyl-CoA-Binding Domain-Containing Protein 3. Activator of Numb

ACBD3

B

132

1

1

[16, 72]

Ligand

Ligand of Numb Protein 2. Negative regulator of Numb

LNX2

K

54

1

1

[72, 87]

Protein

Hairy/enhancer-of-split related with YRPW motif protein 1. Canonical target gene.

HEY1

K

24

3

1

[16]

Receptor

Paired basic amino acid cleaving enzyme. Receptor proteolysis

Furin

B

342

6

11

[16, 72]

Modifier

Protein O-glucosyltransferase. Post-translational maturation of Notch

Poglut

B

500

85

46

[16, 72]

Modifier

Protein O-fucosyltransferase 1. Post-translational maturation of Notch

POFUT1

K

191

5

1

[16, 72]

Modifier

beta-1,3-N-acetylglucosaminyltransferase radical fringe/ Lfng (lunatic) or Rfng (Radical). Post-translational maturation of Notch

Fringe

K

85

4

3

[16]

Repressor

SHARP/ spen family transcriptional repressor/ Mint/Sharp/SPEN, NCoR/SMRT, KyoT2. Co-repressor of RBP-J

MINT

B

95

1

3

[16, 72]

Repressor

Histone deacetylase 1. Co-repressor of RBP-J

HDAC1

K

220

1

0

[72]

Repressor

Nuclear receptor corepressor. Co-repressor of RBP-J

NCoR

B

77

2

0

[16, 72]

Repressor

Co-repressor interacting with RBP-J

CIR1

B

53

2

1

[16, 72]