Fig. 4

Protein protein interaction (PPI) network for the greenyellow module. A The whole PPI network. There were 122 nodes and 238 edges in the network. These nodes (circles) represented genes, and bigger nodes represented genes with more links. Edges (gray lines) between nodes indicated the interaction of genes in the network. Yellow circles represented non DEGs. Red circles represented up-regulated DEGs. Blue circles represented down-regulated DEGs. DEGs (females compared with males). B The PPI sub-network. There were 10 nodes and 34 edges in the network. Color represented Maximal Clique Centrality (MCC) score, and the darker the color, the higher MCC score of the node. Diamond nodes represented down-regulated DEGs. DEGs (females compared with males). Functional enrichment analysis for eight hub genes, including KEGG enrichment analysis (C) and GO enrichment analysis (D). Top 10 terms and top 5 terms ordered by P.adjust for the KEGG and GO enrichment analysis, respectively. P.adjust indicated the degree of enrichment, with smaller P.adjust indicating terms that were more likely to play significantly functional roles