Table 2 Disease association (DA) statistics for transcription factors (TFs) linked to significant SNPs in breast and prostate cancer. Statistics for enhancers identified with 1D and 3D approaches include the number of SNPs used in the analysis, quantiles, and the inter-quantile range (IQR). For each cancer type, DA scores for enhancers and their target genes are reported
Statistic | Breast cancer | Prostate cancer | ||||||
|---|---|---|---|---|---|---|---|---|
TF DA score | DA score for target gene | Fraction of DA-TFsa | DA score for target gene | |||||
1D | 3D | 1D | 3D | 1D | 3D | 1D | 3D | |
# of SNPs | 59 | 459 | 42 | 210 | 986 | 1,387 | 759 | 1,387 |
1st quantile | 2.0 | 10.0 | 2.5 | 4.3 | 0.31 | 0.65 | 1.4 | 3.0 |
2nd quantile | 3.0 | 12.0 | 2.7 | 4.7 | 0.33 | 0.67 | 1.9 | 3.2 |
3rd quantile | 4.0 | 12.0 | 3.0 | 4.9 | 0.34 | 0.69 | 3.0 | 3.7 |
IQR | 2.0 | 2.0 | 0.5 | 0.6 | 0.03 | 0.04 | 1.6 | 0.7 |