From: Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis
SNP | First author | Year | Area | Sample size | Age (y) | Source of control | Genotyping method | Cases | Â | Controls | NOS | HWE | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | Case | Control | M-M−/TT/ AA | M + M−/CT/ AG | M + M+ /CC/ GG |  | M-M−/TT/ AA | M + M−/CT/ AG | M + M+ /CC/ GG | χ2 | P | |||||||
APOB Msp | Cao WJ [25] | 2009 | Xinjiang, China | 100 | 90 | 46 ± 11 | 44 ± 11 | HB | PCR-RFLP | 0 | 4 | 95 |  | 0 | 3 | 87 | 6 | 0.03 | 0.87 |
Chi YH [26] | 2012 | Xinjiang, China | 247 | 221 | 48.7 ± 7.7 | 47.3 ± 6.2 | HB | PCR-RFLP | 9 | 70 | 168 |  | 6 | 67 | 148 | 7 | 0.24 | 0.63 | |
Huang G [20] | 2011 | Xinjiang, China | 275 | 252 | 47.7 ± 7.9 | 48.2 ± 7.6 | HB | PCR-RFLP | 25 | 68 | 182 |  | 22 | 69 | 161 | 8 | 3.43 | 0.06 | |
Jin YN [27] | 2015 | Chongqing,China | 157 | 180 | 48.1 ± 3.8 | 49.1 ± 4.2 | HB | DNA chips | 0 | 26 | 131 |  | 0 | 35 | 145 | 7 | 2.09 | 0.15 | |
Chi YH [21] | 2012 | Xinjiang, China | 200 | 200 | 58.5 ± 11.8 | 58.3 ± 11.5 | PB | PCR-RFLP | 6 | 66 | 128 |  | 12 | 64 | 124 | 7 | 0.91 | 0.34 | |
Selma [28] | 2000 | Sao Paulo, Brazil | 177 | 100 | 58 | 44 | HB | PCR | 2 | 25 | 150 | Â | 1 | 24 | 75 | 6 | 0.37 | 0.54 | |
APOB XbaI | Qian J [29] | 2010 | Yunnan, China | 91 | 76 | 46.9 ± 11.4 | 47.5 ± 8.1 | HB | DNA chips | 0 | 7 | 84 |  | 1 | 11 | 64 | 7 | 0.42 | 0.51 |
Feng JS [30] | 1997 | Guangdong, China | 108 | 128 | 40–70 | HB | DNA probe | 0 | 8 | 100 |  | 0 | 11 | 117 | 6 | 0.26 | 0.61 | ||
Ma ZZ [31] | 2012 | Guangdong, China | 250 | 250 | 45.50 ± 13.20 | PB | PCR-RFLP | 0 | 52 | 198 |  | 0 | 28 | 222 | 8 | 0.88 | 0.35 | ||
Chi YH [26] | 2012 | Xinjiang, China | 247 | 221 | 48.7 ± 7.7 | 47.3 ± 6.2 | HB | PCR-RFLP | 4 | 54 | 189 |  | 3 | 41 | 177 | 7 | 0.13 | 0.72 | |
Xie YJ [22] | 2011 | Xinjiang, China | 150 | 150 | 56.8 ± 10.8 | 58.1 ± 10.5 | HB | PCR-RFLP | 2 | 29 | 119 |  | 0 | 12 | 138 | 7 | 0.26 | 0.61 | |
Jin YN [27] | 2015 | Chongqing,China | 157 | 180 | 48.1 ± 3.8 | 49.1 ± 4.2 | HB | DNA chips | 0 | 28 | 129 |  | 0 | 35 | 145 | 7 | 2.09 | 0.15 | |
Zhang PZ [32] | 2015 | Beijing, China | 100 | 100 | 60.0 ± 5.0 | HB | PCR | 0 | 20 | 80 |  | 0 | 5 | 95 | 8 | 0.07 | 0.8 | ||
Ou HJ [5] | 2015 | Xinjiang, China | 241 | 246 | 49.1 ± 0.7 | 48.3 ± 0.8 | HB | MALDI-TOF | 0 | 19 | 222 |  | 0 | 32 | 214 | 7 | 1.19 | 0.28 | |
Selma [28] | 2000 | Sao Paulo, Brazil | 177 | 100 | 58 | 44 | HB | PCR | 30 | 94 | 53 | Â | 13 | 55 | 32 | 6 | 1.99 | 0.16 | |
Philippa [33] | 1987 | London, U.K. | 133 | 62 | NR | HB | PCR-RFLP | 43 | 59 | 31 | Â | 12 | 38 | 12 | 6 | 3.16 | 0.08 | ||
Gong LG [34] | 2003 | Liaoning, China | 115 | 150 | 54.2 ± 11.7 | 52.5 ± 13.1 | HB | PCR-RFLP | 1 | 29 | 85 |  | 0 | 12 | 138 | 6 | 0.26 | 0.61 | |
CHOONG [35] | 1999 | Singapore | 131 | 173 | NR | HB | PCR-RFLP | 0 | 25 | 106 | Â | 0 | 21 | 152 | 6 | 0.72 | 0.4 | ||
APOB EcorI | Qian J [29] | 2010 | Yunnan, China | 91 | 76 | 46.9 ± 11.4 | 47.5 ± 8.06 | HB | DNA chips | 0 | 13 | 78 |  | 0 | 3 | 73 | 7 | 0.03 | 0.86 |
Ma ZZ [31] | 2012 | Guangdong, China | 250 | 250 | 45.5 ± 13.2 | PB | PCR-RFLP | 0 | 41 | 209 |  | 0 | 28 | 222 | 8 | 0.88 | 0.35 | ||
Huang G [20] | 2011 | Xinjiang, China | 275 | 252 | 47.7 ± 7.9 | 48.2 ± 7.6 | HB | PCR-RFLP | 12 | 73 | 190 |  | 10 | 77 | 165 | 8 | 0.07 | 0.79 | |
Xie YJ [22] | 2011 | Xinjiang, China | 150 | 150 | 56.8 ± 10.8 | 58.1 ± 10.5 | HB | PCR-RFLP | 1 | 55 | 94 |  | 0 | 19 | 131 | 7 | 0.69 | 0.41 | |
Jin YN [27] | 2015 | Chongqing,China | 157 | 180 | 48.1 ± 3.8 | 49.11 ± 4.2 | HB | DNA chips | 0 | 12 | 145 |  | 0 | 20 | 160 | 7 | 0.62 | 0.43 | |
Zhang PZ [32] | 2015 | Beijing, China | 100 | 120 | 60.0 ± 5.0 | HB | PCR | 1 | 19 | 80 |  | 1 | 11 | 108 | 8 | 1.33 | 0.25 | ||
Ou HJ [5] | 2015 | Xinjiang, China | 241 | 246 | 49.1 ± 0.7 | 48.3 ± 0.8 | HB | MALDI-TOF | 1 | 29 | 211 |  | 0 | 22 | 224 | 7 | 0.54 | 0.46 | |
Chi YH [21] | 2012 | Xinjiang, China | 200 | 200 | 58.5 ± 11.8 | 58.3 ± 11.5 | PB | PCR-RFLP | 6 | 52 | 142 |  | 6 | 56 | 138 | 7 | 0.01 | 0.91 | |
CHOONG [35] | 1999 | Singapore | 131 | 173 | NR | HB | PCR-RFLP | 0 | 9 | 122 | Â | 0 | 16 | 157 | 6 | 0.41 | 0.52 | ||
Timirci O [36] | 2010 | Capa-Istanbul, Turkey | 38 | 39 | 11.5 ± 3.6 | 11.4 ± 3.2 | HB | PCR | 0 | 4 | 34 |  | 0 | 4 | 35 | 7 | 0.11 | 0.74 |