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Table 4 The top 40 differentially expressed genes making the greatest contribution to the inter-strain differences in hypothalamic function of ISIAH and WAG rats

From: Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Gene symbol

Acc.#

Correlation

log2 (fold_change) ISIAH/WAG

Definition

Function and/or process

Retsat

NM_145084

0.998

1.82

retinol saturase (all trans retinol 13,14 reductase)

oxidoreductase activity [64]

Sc5d

NM_053642

0.997

1.21

sterol-C5-desaturase

cholesterol biosynthetic process via lathosterol [65] fatty acid metabolic process; lathosterol oxidase activity [66]

RGD1359290

NM_001047898

0.996

was detected in ISIAH but not in WAG

Ribosomal_L22 domain containing protein RGD1359290

structural constituent of ribosome

Abcg2 a

NM_181381

0.994

1.83

ATP-binding cassette, subfamily G (WHITE), member 2

transmembrane transport [67]

Ephx2 a,b

NM_022936

0.993

4.40

epoxide hydrolase 2, cytoplasmic

positive regulation of blood pressure [24]

Fam111a

NM_001109163

0.993

5.12

family with sequence similarity 111, member A

DNA replication [68]

RGD1563482 a

NM_001109065

0.990

0.79

similar to hypothetical protein FLJ38663

aminoacyl-tRNA hydrolase activity

Stra6

NM_001029924

0.990

0.70

stimulated by retinoic acid 6

transports retinol across the cell membrane [18]

Aox2

NM_001008522

0.985

1.47

aldehyde oxidase 2

oxidoreductase activity

Fhit

NM_021774

0.983

1.46

fragile histidine triad

nucleotide metabolic process [69]

Tekt4

NM_001013965

0.981

1.00

tektin 4

protein binding [70]

LOC689064

NM_001111269

0.980

3.23

beta-globin

oxygen transporter activity

Grhl3

NM_001106690

0.976

1.37

grainyhead-like 3 (Drosophila)

may stimulate migration of endothelial cells [71]

Acad9

NM_181768

0.975

0.59

acyl-CoA dehydrogenase family, member 9

oxidoreductase activity catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA

Tgfb2 a

NM_031131

0.975

0.85

transforming growth factor, beta 2

promotes the survival of dopaminergic neurons [37]

Spg7

NM_181388

0.975

0.58

spastic paraplegia 7 homolog (human)

metalloendopeptidase activity [72] nervous system development [73]

Idnk

NM_001037362

0.974

0.91

idnK, gluconokinase homolog (E, coli)

gluconokinase activity

Lyz2

NM_012771

−0.968

−0.68

lysozyme 2

lysozyme activity

Mal a

NM_012798

−0.971

−0.72

mal, T-cell differentiation protein

myelination [74]; structural constituent of myelin sheath [75]

Lcat

NM_017024

−0.972

−0.77

lecithin cholesterol acyltransferase

phospholipase A2 activity [76] cholesterol metabolic process [77]

PCOLCE2

NM_001127640

−0.972

−2.12

procollagen C-endopeptidase enhancer 2

collagen binding [78]

RT1-S3

NM_001008886

−0.974

−2.03

RT1 class Ib, locus S3

antigen processing and presentation of peptide antigen via MHC class I

Cst3 a,b

NM_012837

−0.976

−0.59

cystatin C

prevents oxidative stress-induced death [44]

Cyp2j10

NM_001134980

−0.977

−0.94

cytochrome P450, family 2, subfamily j, polypeptide 10

EETs biosynthesis [79]

Gstm4

NM_001024304

−0.978

−1.75

glutathione S-transferase mu 4

glutathione binding glutathione metabolic process

Grm2

NM_001105711

−0.979

−1.81

glutamate receptor, metabotropic 2

regulation of synaptic transmission, glutamatergic [80]

Mx2

NM_134350

−0.979

−1.29

myxovirus (influenza virus) resistance 2

innate immune response [81]

Zfp385d

NM_001013992

−0.980

−0.74

zinc finger protein 385D

zinc ion binding

Tnnt1

NM_001277260

−0.981

−4.37

troponin T type 1 (skeletal, slow)

regulation of muscle contraction [82]

Cpz

NM_031766

−0.982

−0.89

carboxypeptidase Z

zinc ion binding metallocarboxypeptidase activity extracellular matrix homeostasis

Pyroxd2

NM_001004261

−0.983

−2.86

pyridine nucleotide-disulphide oxidoreductase domain 2

oxidoreductase activity

Rbp4

NM_013162

−0.985

−1.49

retinol binding protein 4, plasma

retinol transporter activity [83]

Abca8a

NM_001281824

−0.987

−0.65

ATP-binding cassette, subfamily A (ABC1), member 8a

transporter activity lipid transport transmembrane transport

Mpeg1

NM_022617

−0.989

−2.31

macrophage expressed 1

 

Grifin

NM_057187

−0.989

−4.44

galectin-related inter-fiber protein

carbohydrate binding

Ltbp2 b

NM_021586

−0.989

−2.88

latent transforming growth factor beta binding protein 2

decreases fibroblast adhesion to fibronectin [84] negatively regulates coalescence of oxytalan fibers induced by stretching stress [85]

Snx14

NM_001108174

−0.990

−0.85

sorting nexin 14

phosphatidylinositol-3,5-bisphosphate binding [86]

Pnpla1

NM_001191841

−0.993

−2.59

patatin-like phospholipase domain containing 1

lipid catabolic process

RT1-A2

NM_001008829

−0.993

−1.98

RT1 class Ia, locus A2

antigen processing and presentation of peptide antigen via MHC class I

RGD1309362

NM_001024884

−0.995

−2.46

similar to interferon-inducible GTPase

 
  1. Genes associated with: acentral nervous system diseases; b-hypertension; ISIAH and WAG – rat strains used in the study