Schematic of the sequence changes of Nppc gene in lbab mice. A: A stretch of nucleotide sequence of Nppc in lbab/lbab and +/+ mice. A C→G transversion was found in both genomic DNA and cDNA sequences of Nppc in lbab/lbab mice compared with the sequence from PL/J mice. B: Alignment of the predicted amino acid sequence in the conserved domain of Nppc in different species. The C→G substitution leads Arg (R) to Gly (G) substitution at codon 117 on the conserved domain of Nppc.